TY - JOUR ID - 92929 TI - The potentiality of the functionalized nitrogen and thiol-doped graphene quantum dots (GQDs-N-S) to stabilize the antibodies in the designing of human chorionic gonadotropin immunosensor JO - Nanochemistry Research JA - NCR LA - en SN - 2538-4279 AU - Roushani, Mahmoud AU - Valipour, Akram AU - Bahrami, Mehrangiz AD - Department of Chemistry, Ilam University, Ilam, Iran AD - Department of Chemistry, Yasouj University, Yasouj, Iran Y1 - 2019 PY - 2019 VL - 4 IS - 1 SP - 20 EP - 26 KW - Screen Printed Carbon Electrode KW - Nitrogen and thiol-doped graphene quantum dots KW - Immunosensor DO - 10.22036/ncr.2019.01.003 N2 - In this study, for the first time, a simple immunosensor for ultrasensitive recognition of Human Chorionic Gonadotropin (hCG) in serum samples was fabricated by exploiting a simple approach. In this method, a low-cost and sensitive immunosensor was fabricated based on QDs-N-S/Au nanoparticles (NPs) modified Screen-Printed Carbon Electrode (SPCE). It seems that, QDs-N-S/Au NPs/ antibody as a biocomposite can be a good choice for the development of an impressive immunosensor. It must be said that in the modifying of immunosensor the length of the process have been reduced and the use of another substrates have been eliminated. pH and incubation time were optimized as two important parameters. Under the optimal conditions at modified SPCE, a linear communication in the range of 0.1 to 125 pg mL−1 and the detection limit of 12.5 fg mL−1 were obtained. The present procedure was utilized to the detection of hCG in real samples with the desirable results. UR - http://www.nanochemres.org/article_92929.html L1 - http://www.nanochemres.org/article_92929_0aebc1fbd6c7755bc80c0ea0d50aa4cb.pdf ER -